Introduction to 2-Bromo-3-Methylpropiophenone

2-Bromo-3-Methylpropiophenone is an organic compound with the molecular formula C10H11BrO. It belongs to the class of aromatic ketones and is widely used as an intermediate in pharmaceutical synthesis and organic chemistry research. This compound is characterized by its bromine substitution at the 2-position and a methyl group at the 3-position of the propiophenone backbone.

Chemical Properties

The chemical properties of 2-Bromo-3-Methylpropiophenone make it a valuable compound in various applications. Below are some of its key characteristics:

• Molecular Weight: 227.10 g/mol
• Appearance: Typically a white to off-white crystalline powder
• Melting Point: Approximately 60-65°C
• Solubility: Soluble in organic solvents like ethanol, methanol, and acetone; slightly soluble in water
• Stability: Stable under normal conditions but should be stored away from light and moisture

Synthesis Methods

2-Bromo-3-Methylpropiophenone can be synthesized through several methods, including:

1. Friedel-Crafts Acylation: This involves the reaction of bromobenzene with 3-methylpropanoyl chloride in the presence of a Lewis acid catalyst like aluminum chloride.
2. Bromination of 3-Methylpropiophenone: Direct bromination of 3-methylpropiophenone using bromine or N-bromosuccinimide (NBS) under controlled conditions.

Industrial and Pharmaceutical Applications

2-Bromo-3-Methylpropiophenone serves as a crucial intermediate in several industries:

Safety and Handling

Proper handling of 2-Bromo-3-Methylpropiophenone is essential due to its reactive nature. Key safety measures include:

• Use personal protective equipment (PPE) such as gloves and goggles.
• Store in a cool, dry place away from incompatible substances.
• Avoid inhalation or direct contact with skin and eyes.

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