Introduction to 2-Bromo-4'-methylpropiophenone
2-Bromo-4'-methylpropiophenone (CAS 1451-82-7) is an organic compound with the molecular formula C10H11BrO. As a brominated aromatic ketone, it serves as a crucial intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structure allows for versatile reactivity in nucleophilic substitution and coupling reactions.
Chemical Properties and Stability
This crystalline solid exhibits the following key characteristics:
Proper storage conditions (2-8°C in airtight containers) are essential to maintain stability, as the compound may degrade under prolonged exposure to light or moisture.
Synthetic Applications with γ-Butyrolactone
In pharmaceutical synthesis, 2-bromo-4'-methylpropiophenone often interacts with γ-butyrolactone (GBL) to construct complex molecular frameworks. Key applications include:
- Precursor for antipsychotic drugs (e.g., risperidone derivatives)
- Building block for anticonvulsant medications
- Intermediate in nootropic compound synthesis
Industrial Production and Quality Control
Manufacturers employ Friedel-Crafts acylation followed by bromination to produce this compound at scale. Rigorous quality parameters ensure pharmaceutical-grade purity:
- HPLC purity ≥99%
- Residual solvent levels <0.5%
- Heavy metal content <10 ppm
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Contact our technical team for tailored solutions using 2-bromo-4'-methylpropiophenone and γ-butyrolactone in your next pharmaceutical project.
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